THE IVAN BRAIN TUMOR LAB

Dr. Ivan combines clinical and basic science research to accelerate the bench to bedside approach in neuro-oncology.  The goal of the lab is to discover new biomarkers, drug delivery methods, and treatments for brain tumors.  After successful removal of brain tumors, tissue is brought to the Ivan Lab where patient derived stem cell cultures and xenografts are developed.  This allows a personalized medicine approach to the discovery of brain tumor treatment, which translates in to improved success for laboratory prediction of patient tumor response.   

Clinical research is also ongoing to understand and improve outcomes in brain tumor therapy.  Ongoing clinical research includes the investigation of minimally invasive brain tumor management with state of the art treatments, including endoscopic approaches, laser interstitial thermal therapy, fluorescence guided surgery, and radiosurgery.  

Recent research publications:

Resection versus biopsy in the treatment of multifocal glioblastoma: a weighted survival analysis.

Di L, Heath RN, Shah AH, Sanjurjo AD, Eichberg DG, Luther EM, de la Fuente MI, Komotar RJ, Ivan ME.J Neurooncol. 2020 May;148(1):155-164. doi: 10.1007/s11060-020-03508-6. Epub 2020 May 11.PMID: 32394325

Geographic disparities in access to glioblastoma treatment based on Hispanic ethnicity in the United States: Insights from a national database.

Lu VM, Shah AH, Eichberg DG, Quinones-Hinojosa A, Esquenazi Y, Komotar RJ, Ivan ME.J Neurooncol. 2020 May;147(3):711-720. doi: 10.1007/s11060-020-03480-1. Epub 2020 Mar 31.PMID: 32236779

Incidence of high grade gliomas presenting as radiographically non-enhancing lesions: experience in 111 surgically treated non-enhancing gliomas with tissue diagnosis.

Eichberg DG, Di L, Morell AA, Shah AH, Semonche AM, Chin CN, Bhatia RG, Jamshidi AM, Luther EM, Komotar RJ, Ivan ME.J Neurooncol. 2020 May;147(3):671-679. doi: 10.1007/s11060-020-03474-z. Epub 2020 Mar 27.PMID: 32221785

Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks.

Hollon TC, Pandian B, Adapa AR, Urias E, Save AV, Khalsa SSS, Eichberg DG, D'Amico RS, Farooq ZU, Lewis S, Petridis PD, Marie T, Shah AH, Garton HJL, Maher CO, Heth JA, McKean EL, Sullivan SE, Hervey-Jumper SL, Patil PG, Thompson BG, Sagher O, McKhann GM 2nd, Komotar RJ, Ivan ME, Snuderl M, Otten ML, Johnson TD, Sisti MB, Bruce JN, Muraszko KM, Trautman J, Freudiger CW, Canoll P, Lee H, Camelo-Piragua S, Orringer DA.Nat Med. 2020 Jan;26(1):52-58. doi: 10.1038/s41591-019-0715-9. Epub 2020 Jan 6.PMID: 31907460

Drug and disease signature integration identifies synergistic combinations in glioblastoma.

Stathias V, Jermakowicz AM, Maloof ME, Forlin M, Walters W, Suter RK, Durante MA, Williams SL, Harbour JW, Volmar CH, Lyons NJ, Wahlestedt C, Graham RM, Ivan ME, Komotar RJ, Sarkaria JN, Subramanian A, Golub TR, Schürer SC, Ayad NG.Nat Commun. 2018 Dec 14;9(1):5315. doi: 10.1038/s41467-018-07659-z.PMID: 30552330

A designer bow-tie combination therapeutic platform: An approach to resistant cancer treatment by simultaneous delivery of cytotoxic and anti-inflammatory agents and radiation.

Pathak RK, Basu U, Ahmad A, Sarkar S, Kumar A, Surnar B, Ansari S, Wilczek K, Ivan ME, Marples B, Kolishetti N, Dhar S.Biomaterials. 2018 Dec;187:117-129. doi: 10.1016/j.biomaterials.2018.08.062. Epub 2018 Sep 5.PMID: 30336364

Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme.

Tan SK, Pastori C, Penas C, Komotar RJ, Ivan ME, Wahlestedt C, Ayad NG.Mol Cancer. 2018 Mar 20;17(1):74. doi: 10.1186/s12943-018-0822-0.PMID: 29558959

Fluorescent Detection of Merlin-deficient Schwann Cells and Primary Human Vestibular Schwannoma Cells Using Sodium Fluorescein.

Perez ER, Bracho O, Ein L, Szczupak M, Monje PV, Fernandez-Valle C, Alshaiji A, Ivan M, Morcos J, Liu XZ, Hoffer M, Eshraghi A, Angeli S, Telischi F, Dinh CT.Otol Neurotol. 2018 Sep;39(8):1053-1059. doi: 10.1097/MAO.0000000000001895.PMID: 30001282

Laser Ablation of Newly Diagnosed Malignant Gliomas: a Meta-Analysis.

Ivan ME, Mohammadi AM, De Deugd N, Reyes J, Rodriguez G, Shah A, Barnett GH, Komotar RJ.Neurosurgery. 2016 Dec;79 Suppl 1:S17-S23. doi: 10.1227/NEU.0000000000001446.PMID: 27861322 Review.

Management of Atypical and Anaplastic Meningiomas.

Buttrick S, Shah AH, Komotar RJ, Ivan ME.Neurosurg Clin N Am. 2016 Apr;27(2):239-47. doi: 10.1016/j.nec.2015.11.003. Epub 2016 Feb 20.PMID: 27012388 Review.